(Image created by Digizyme, Inc.)
DAEDALUS: DNA Origami Sequence Design Algorithm for User-defined Structures
Synthetic DNA can be programmed to robustly self-assemble into pre-defined nanoscale structures of nearly arbitrary 3D shape using the principle of scaffolded DNA origami, invented by Dr. Paul Rothemund in 2006. This website offers the free online resource DAEDALUS that automatically converts any 3D solid object specified using a simple Computer-Aided Design file into the synthetic DNA sequences that are needed to synthesize the target object. In short, DAEDALUS offers the ability to “print” your 3D nanometer-scale geometry in DNA.
For more information on our approach, please see this accompanying article by Veneziano, Ratanalert, et al., Science, 2016 and the About page.